GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs8030605 | 1 | rs58934221 | chr15:56516381 | TEX9 | chr15:56657644-56738071:+ | -0.34 | -5.8 | 1.21E-8 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs7679 | 1 | rs58952297 | chr20:44560820 | WFDC3 | chr20:44402847-44420547:- | -0.27 | -3.89 | 0.000114 | HDL cholesterol;Triglycerides;Gut microbiota (functional units) |
| THCA | cis | rs3136441 | 1 | rs5896 | chr11:46745003 | ZNF408 | chr11:46722368-46727461:+ | -0.18 | -3.5 | 0.000508 | HDL cholesterol |
| THCA | cis | rs589756 | 1 | rs589756 | chr6:132643117 | MOXD1 | chr6:132617195-132722664:- | 0.27 | 4.67 | 3.99E-6 | Obesity-related traits |
| THCA | cis | rs73201462 | 1 | rs58986862 | chr3:128061689 | EEFSEC | chr3:127872313-128127488:+ | -0.23 | -3.99 | 7.56E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs7116495 | 1 | rs58991229 | chr11:71839878 | FAM86C | chr11:71498557-71512276:+ | -0.29 | -3.56 | 0.000408 | Severe influenza A (H1N1) infection |
| THCA | cis | rs2129782 | 1 | rs58994609 | chr8:89438194 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |
| THCA | cis | rs12304921 | 1 | rs58999537 | chr12:51357104 | SLC11A2 | chr12:51373319-51422058:- | -0.24 | -4.83 | 1.87E-6 | Type 2 diabetes |
| THCA | cis | rs12304921 | 1 | rs58999537 | chr12:51357104 | TFCP2 | chr12:51488608-51566917:- | -0.2 | -4.28 | 2.25E-5 | Type 2 diabetes |
| THCA | cis | rs8030605 | 1 | rs59025920 | chr15:56409172 | MNS1 | chr15:56720929-56757335:- | -0.25 | -3.65 | 0.000287 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs8030605 | 1 | rs59025920 | chr15:56409172 | TEX9 | chr15:56657644-56738071:+ | -0.35 | -6.01 | 3.6E-9 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs2129782 | 1 | rs59030724 | chr8:89414702 | MMP16 | chr8:89049462-89339717:- | 0.32 | 5.1 | 4.9E-7 | Electrodermal activity |
| THCA | cis | rs6479891 | 1 | rs59035163 | chr10:65292043 | LOC84989 | chr10:65224989-65226320:+ | 0.26 | 4.18 | 3.5E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs6479891 | 1 | rs59035163 | chr10:65292043 | NRBF2 | chr10:64893007-64914785:+ | 0.26 | 4.36 | 1.59E-5 | Arthritis (juvenile idiopathic) |
| THCA | cis | rs2129782 | 1 | rs59043278 | chr8:89444592 | MMP16 | chr8:89049462-89339717:- | 0.33 | 5.31 | 1.72E-7 | Electrodermal activity |